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Book Details :
Published on: 1985-08-15
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Original language: English
The human leukocyte antigen (HLA) or tissue types are the products of a rapidly developing field of knowledge within the last 20 years. In the early stages of the research many investigators suspected the existence of a complex series of transplantation antigens, but it was widely believed that these antigens would not be well-defined even in this century. Yet in the last two decades as many as 124 different HLA antigens determined by at least 7 very closely linked genes located on the short arm of chromosome 6 have been identified and subsequently agreed upon by an international nomenclature committee. 1 Extensive international collaboration fueled by the potential clinical application of these antigens to clinical transplantation has advanced the field rapidly. There were nine inter national histocompatibility workshops held during this period. Although iden tification of HLA antigens was of primary clinical importance in transplantation 2 and of great basic interest in human genetics and anthropology, a rather un expected bonus has been the determination that HLA antigens are associated with disease susceptibility to a greater extent than any other known genetic marker in man. In the past, many genetic polymorphisms have been suspected to be associated with diseases. The most extensively studied markers are blood groups, enzymes, and serum proteins. A comprehensive account of published studies, totalling approximately 1,000, of these markers is available in a book by Mourant et al. HLA Disease Associations The Autoimmune Diseases site The association between genetics particularly the genes of the Major Histocompatibility Complex (MHC) and many autoimmune diseases has long been known even though ... HLA-B27 - Wikipedia Disease associations. The relationship between HLA-B27 and many diseases has not yet been fully elucidated. Though it is associated with a wide range of pathology ... Genetics of Celiac Disease: Overview Clinical ... Celiac disease (CD) is an immune-mediated disease of the intestines that is triggered by the ingestion of gluten in genetically susceptible individuals. Behcet's disease - SlideShare Behcet's disease 1. BEHCETS DISEASE AND ITS ASSOCIATIONS Moderator : Dr. Puneet Bhargava 2. INTRODUCTION First described in ... HLA57/89346 HLA-B 5701 Genotype Abacavir Hypersensitivity HLA57 : Identifying individuals with an increased risk of hypersensitivity reactions to abacavir based on the presence of the human leukocyte antigen HLA-B*57:01 allele HLA-B51 - Wikipedia HLA-B51 (B51) is an HLA-B serotype. The serotype identifies the more common HLA-B*51 gene products. B51 is a split antigen of the broad antigen B5 and is a sister ... Cord-Blood Transplantation in Patients with Minimal ... Conclusions. Our data suggest that among patients with pretransplantation minimal residual disease the probability of overall survival after receipt of a transplant ... Inflammatory Myopathy Neuromuscular Home Page Skin lesions 74. Disease associations Dermatomyositis Childhood type; Skin disorders with other immune myopathy syndromes Jo-1 & t-RNA synthetase antibody HLA-H Gene - GeneCards HLA-H Pseudogene Complete information for HLA-H gene (Pseudogene) Major Histocompatibility Complex Class I H (Pseudogene) including: function proteins disorders pathways ... MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II DQ BETA-1; HLA ... The genes for the heteromeric major histocompatibility complex class II proteins the alpha and beta subunits are clustered in the 6p21.3 region.
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